A man injured in a shooting accident received the entire facial skin and muscles - including cheekbones, nose, lips and teeth - of a donor.
The man is recovering well after the 22-hour operation, said a spokesperson from Vall d'Hebron University Hospital.
Another 10 face transplants have been carried out around the world, but this is believed to be the most complex.
Hospital spokesperson Bianca Bont told the BBC: "This is the first total face transplant.
"There have been 10 operations of this kind in the world - this is the first to transplant all of the face and some bones of the face."
BBC News
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